With a voice that has been described as "pure, lovely, vibrant, truthful, and lustrous," Claire Vangelisti has found success on both national and international stages, singing repertoire from Bach to Berg. Vangelisti made her American operatic debut with Austin Opera, where she performed several cameo roles in mainstage productions such as Rigoletto, The Ballad of Baby Doe, as well as the role of Papagena in Die Zauberflöte. Vangelisti has performed with companies such as the  Lyric Opera of San Antonio, Southwest Opera, and Louisiana Opera to name a few.

Vangelisti has been engaged extensively as a concert soloist and is an avid champion of the music of living composers, and performed the World Premiere of Letting Go, a song cycle by composer Daron Hagen, in the Fall of 2002. In in 2013, Vangelisti performed the American Premiere of two song cycles by Portuguese composer Eurico Carrapatoso, and she continues to disperse Carrapatoso's music to the U.S. audience. She has also collaborated with artists such as Libby Larsen, John Harbison, Daron Hagen, Lowell Liebermann, William Bolcom, Frank Ticheli, Stephen Paulus, Jake Hegge, and Eric Ewazen.

Vangelisti holds a Doctorate of Musical Arts from the University of Texas at Austin and is currently Associate Professor and Voice Program Coordinator at the University of Louisiana at Monroe.